Group Members

 

Dr. Martin Stillman

  • B. Sc and Ph. D. University of East Anglia (Norwich, UK)
  • PDF University of Alberta, Canada
  • Professor of Chemistry; cross-appointed as Professor of Biology
    Associate Chair, Chemistry (undergraduate education policy)
    2011-2015
  • You can find Martin's research description also on LINKEDIN (Martin Stillman) and Research Gate (Martin Stillman)
  • The group is also represented on facebook.com as
  • "/martin.stillman" and "/stillmanbioinorganicgroup"
  • Our group also hosts "/chemistryatwestern" and /canbic.ca" pages
  • www.facebook.com/stillmanbioinorganicgroup - for more pictures
  • www.facebook.com/canbic.ca - for news of the CanBIC conference (also www.canbic.ca)
  • www.facebook.com/martin.stillman
  • www.facebook.com/chemistryatwestern
  •  
  • Please like or even be our friend!
  •  

 
The group on October, 2015

 

Climbing an active volcano near Sendai with Nagao Kobayashi and friends in 2014


Lunch on a busy Saturday at the end of the summer in 2014

Tiffany Jeen, Daisy Wong, Tyler Pinter, Gordon Irvine, Martin Stillman

 

The group in late November in the newly renovated desk room


Group

Inorganic Discussion Weekend, York University (Nov. 2013)

 

Summer 2013

At CanBIC-3 (May 2013) on the Thousand Island Cruise - Gordon, Tyler, Mike, Martin, Nagao, Jasjit, Brit, Maria


Group

Lunch - yes, always eating or drinking! Mike, Gordon, Tyler, Martin, Maria, Brit - April 2013

 

Group long time ago: Mike, Martin, Thanh, Duncan, Tyler

Current Group

 Gordon Irvine

  • Currently working towards his Ph. D.
  • Supported by a 3 year NSERC Canada Graduate Scholarship (CGSD3)
  • B.Sc. Brock University (2012)

Publications

Irvine GW, Stillman MJ. (2016) “Cadmium binding mechanisms of isolated domains of human MT isoform 1a: Non-cooperative terminal sites and cooperative cluster sites.” J. Inorganic Biochemistry, doi:10.1016/j.jinorgbio.2016.03.001

Irvine GW, Pinter TB, Stillman MJ. (2016) “Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion.” Metallomics (see cover art)

Pinter, T.B.J.; Irvine, G.W.;Stillman, M.J.  (2015) "Domain selection in metallothionein 1A: Affinity controlled mechanisms of zinc binding and cadmium exchange", Biochemistry.54(32):5006-16. doi: 10.1021/acs.biochem.5b00452. Selected for highlight by Biochemistry

Gordon W. Irvine , Kelly E. R. Duncan, Meredith Gullons and Martin J. Stillman (2015) "Metalation kinetics of the human α-metallothionein 1a fragment is dependent on the fluxional structure of the apo-protein", Chemistry - A European Journal, 21, 1269-1279. http://dx.doi.org/10.1002/chem.201404283.

Irvine
, G.W.; Stillman, M.J. (2013) "Topographical analysis of As-induced folding of alpha-MT1a." Biochem. Biophys. Res. Commun. 441, 208-213. doi: 10.1016/j.bbrc.2013.10.044.

Irvine
, G.W.; Summers, K.L.; Stillman, M.J. (2013) "Cysteine accessibility during As3+ metalation of the alpha and beta-domains of recombinant human MT1a.". Biochem. Biophys. Res. Commun., 433, 477-483.

  Conference presentations

  • Irvine, GW; Stillman, MJ "Protein-protein interaction and structural properties revealed through covalent labeling and ESI-MS of metallothionein", Poster Presentation at the 2015 Gordon Research Conference - Metals in Biology, California , USA. 25-31 Jan, 2015
    Irvine, GW; Stillman, MJ "Analyzing the structure of apo-metallothionein using ESI-MS and covalent labeling", Chemistry Graduate Student Symposium, University of Buffalo, Buffalo, New York. May 19-21, 2014. Irvine , GW; Rigby-Duncan, KE; Stillman, MJ "Conformational Analysis of Apo-Metallothionein Using ESI-MS and Molecular Probes.", 12th Int Symp on Applied Bioinorganic Chemistry, Guangzhou, China, 3-6 Dec., 2013 Irvine, RW; Stillman, MJ "Using molecular probes to examine the surface topography of apo- and partially metalated metallothionein" 4th Georgian Bay International Conference on Bioinorganic Chemistry, Parry Sound, Ontario, 21st - 25th May, 2013.

    Daisy Wong

    • B.Sc. The University of Western Ontario(2014)
    • Currently working towards PhD
    • Supported by an OGS Postgraduate Scholarship
    •  
    • Publications
    • Wong, DL, Stillman MJ. (2016) “Destructive interactions of dirhodium (ii) tetraacetate with β metallothionein rh1a.” Chemical Communication. 52, 5698 - 5701 DOI: 10.1039/C5CC10319C

    • Conference presentations
    Wong, D.L.; Stillman, M.J. " The Destructive Interaction of Dirhodium(II) Tetraacetate and Human Metallothionein", Inorganic Discussion Weekend (IDW ), U.Montreal, 14-16 Nov. 2014.
  • Wong, DL; Stillman MJ "Running the gauntlet: Interactions of metallodrugs with metallothionein" 97th Canadian Chemistry Conference and Exposition, Vancouver . 1-6 June, 2014.
  • Wong, D.L.; Stillman. M.J. "Running the Gauntlet: Destruction of Metallodrugs by Human Metallothionein I", Chemistry Graduate Student Symposium, University of Buffalo, Buffalo, New York. May 19-21, 2014.
  • Wong, D.L.; Sutherland, D.E.K.; Stillman. M.J. "Running the Gauntlet: Interactions of Organometallodrugs with Metallothionein", 46th Inorganic Discussion Weekend, York University, Toronto, Ontario. , Nov 8-10th, 2013.
  • Devika Jayawardena
  • Angel Zhang

    • B.Sc. The University of Western Ontario (2016)
    • Currently working towards MSc
    •  
    • Publications
    • Yamamoto, S.; Zhang, A.; Stillman, M.J.; Kobayashi, N.; Kimura, M. (2016) “Low symmetry Omega-shaped zinc phthalocyanine sensitizers having a panchromatic light-harvesting property for dye sensitized solar cells” Chemistry: A European Journal, in press. DOI: 10.1002/chem.201603705

    • Conference presentations
  • Zhang, QW, Yamamoto, S, Kwan, L, Kobayashi, N, Kimura, M, Stillman, MJ. “Computational and spectroscopic studies in the design of novel porphyrins for solar cell applications. International Conference on   Porphyrins and Phthalocyanines (ICPP) 9-Nanjing, China – 2016 July 3-8 (poster)
  • Angel Zhang and Martin J. Stillman “Computational and Spectroscopic Studies in the Design of Novel Porphyrins for Solar Cell Applications” May 16 – 18th, 2016 Graduate Student Symposium, held at the University at Buffalo, Buffalo, New York, USA
  • Zhang, QW, Yamamoto, S, Kwan, L, Kobayashi, N, Kimura, M, Stillman, MJ. “Computational and spectroscopic studies in the design of novel porphyrins for solar cell applications”. Fallona Family Interdisciplinary Showcase, The University of Western Ontario, London, Ontario, Canada Dec 8, 2015

  • Judith Scheller
  • Lina Heinlein
  •  

    ---------------------------------------------------

    The group on the Island Queen during CanBIC-4 (see www.canbic.ca and fb "canbic") May, 2013.

    ---------------------------------------

      Past Group Members by date order is based on finally leaving the group!

    Tyler Pinter

    • B.Sc. The University of Western Ontario (2009); PhD (2015)
    • Currently working at the University of Michigan as a PDF
    • Supported by a 3 year NSERC Postgraduate Scholarship
    • Publications

     

    Irvine GW, Pinter TB, Stillman MJ. (2016) “Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion.” Metallomics, 2016, 8, 71-81 DOI: 10.1039/C5MT00225G Metallomics (see cover art)

     

    Laakso HA, Marolda CL, Pinter TB, Stillman MJ, Heinrichs DE. (2015) A heme-responsive regulator controls synthesis of staphyloferrin B in Staphylococcus aureus. J Biol Chem. 2015 Nov 3. pii: jbc.M115.696625.

     

    Pinter, T.B.J.; Stillman, M.J. (2015) "Kinetics of Zinc and Cadmium Exchanges between Metallothionein and Carbonic Anhydrase"; Biochemistry. 54(40):6284-93. doi: 10.1021/acs.biochem.5b00912.

     

    Pinter, T.B.J.; Stillman, M.J. (2015) "Putting the pieces into place: Properties of intact zinc metallothionein 1A determined from interaction of its isolated domains with carbonic anhydrase", Biochemical Journal 471 (3) 347-356; DOI:

    10.1042/BJ20150676.

     

    Pinter, T.B.J.; Irvine, G.W.;Stillman, M.J. (2015) "Domain selection in metallothionein 1A: Affinity controlled mechanisms of zinc binding and cadmium exchange", Biochemistry.54(32):5006-16. doi: 10.1021/acs.biochem.5b00452. Selected for highlight by Biochemistry.

     

    Pinter, T.; Stillman, M.J. (2014) " The Zinc Balance: Competitive Zinc Metalation of Carbonic Anhydrase and Metallothionein 1A", Biochemistry , 2014, 53 (39), pp 6276-6285. DOI: 10.1021/bi5008673.

     

    Tiedemann, M.T.; Pinter, T.B.J.; Stillman, M.J. (2012) "Insight into blocking heme transfer by exploiting molecular interactions in the core Isd heme transporters IsdA-NEAT, IsdC-NEAT and IsdE of Staphylococcus aureus", Metallomics, 4, 751-760. DOI: 10.1039/C2MT20067H (featured on cover). (TOP 10 downloads in July, 2012)

     

    Bohle, D.S.; Dodd, E.L.;Pinter, T.B.J.; Stillman, M.J. (2012) "Soluble diamagnetic model for malaria pigment: coordination chemistry of gallium(III) protoporphyrin-IX", Inorg. Chem., 51:10747-61. DOI: 10.1021/ic301106g

     

    Pinter, T.B.J.; Dodd, E.L.; Bohle, D.S.; Stillman, M.J. (2012) "Spectroscopic and Theoretical Studies of Ga(III)protoporphyrin-IX and Its Reactions with Myoglobin", Inorg. Chem. 51, 3743-3753. doi: 10.1021/ic202731g

     

    T. Ngu;, J.A. Lee; T.B.J. Pinter; M.J. Stillman (2010) "Arsenic-Metalation of Triple Domain Human Metallothioneins: Support for the Evolutionary Advantage and Interdomain Metalation of Multiple-Metal-Binding Domains", J. Inorg. Biochem., 104, 232-244.

     

    Conference presentations

    Pinter, T.B.J., Jeen, T., Stillman, M.J. "Domain Specificity in Metal Coordination by Metallothionein 1A". Oral Presentation at the 19th Bioinorganic Chemistry Gordon Research Seminar. California , USA . 31 Jan - 2 Feb, 2015.

    Tyler B.J. Pinter and Martin J. Stillman. "The Competitive Zinc Metallation of Metalloenzymes with Metallothionein." Poster Presentation at the 2015 Gordon Research Conference - Metals in Biology, California , USA. 25-31 Jan, 2015

    Jeen, T; Pinter, T.B.J., Stillman, M.J. " Challenging Domain Specificity: Bioinorganic Metal Distribution in the Two Domains of Metallothionein", Chemistry Research Awards Day, Dept. of Chemistry, U. Saskatchewan, October, 2014 (Ms Jeen won the Runner's Up and People's Choice Awards).

    Jeen, T; Pinter, T.B.J., Stillman, M.J. " Challenging Domain Specificity: Bioinorganic Metal Distribution in the Two Domains of Metallothionein", Inorganic Chemistry Exchange (ICE) Workshop, St. John's , Newfoundland , 21-22 Aug., 2014.

    Pinter, T.B.J., Stillman, M.J. "The competitive zinc metallation of metallothionein in the presence of carbonic anhydrase." 97th Canadian Chemistry Conference and Exposition, Vancouver. June 1-6, 2014

    Jeen, T; Pinter, T.B.J., Stillman, M.J. "Metallation of beta-a Metallothionein", 31st Chemistry Graduate Student Symposium, Buffalo , New York . May 19-21, 2014.

    Pinter, T.B.J.*, Stillman, M.J. Determining the Zinc Binding Constants of Metallothionein in the Presence of Carbonic Anhydrase. 31st Chemistry Graduate Student Symposium, Buffalo , New York . May 19-21, 2014.

    Pinter, TBJ; Stillman, MJ "Implications of metallothionein in apoenzyme metallation" International Conference on Bioinorganic Chemistry (ICBIC-16), Grenoble, France, 22-26 July, 2013.

    Pinter, T.B.J.; Stillman, M.J. "Exploring Metal Transfer between Metallothioneins and Metalloenzymes" Gordon Research Conference - Metals in Biology / Bioinorganic Chemistry Seminar Ventura , California . January 22-29, 2012.

    Pinter, T.B.J.; Dodd, E.L.; Bohle, D.S.; Stillman, M.J., "Spectroscopic and theoretical studies of GaPPIX binding to myoglobin", 3rd Georgian Bay International Conference on Bioinorganic Chemistry (CanBIC-3), Parry Sound , Ontario . May 31 - June 3, 2011

      Tiffany Jeen

    • B.Sc. The University of Saskatchewan (2016)
    • 2014 Inorganic Chemistry Exchange (ICE) Scholar
      Summer stipend supported by an USRA award.

    Conference and workshop presentations
  • Pinter, T.B.J., Jeen, T., Stillman, M.J. "Domain Specificity in Metal Coordination by Metallothionein 1A". Oral Presentation at the 19th Bioinorganic Chemistry Gordon Research Seminar. California , USA . 31 Jan - 2 Feb, 2015. 
  • Jeen, T; Pinter, T.B.J., Stillman, M.J. " Challenging Domain Specificity: Bioinorganic Metal Distribution in the Two Domains of Metallothionein", Chemistry Research Awards Day, Dept. of Chemistry, U. Saskatchewan, October, 2014 (Ms Jeen won the Runner's Up and People's Choice Awards).
  • Jeen, T; Pinter, T.B.J., Stillman, M.J. " Challenging Domain Specificity: Bioinorganic Metal Distribution in the Two Domains of Metallothionein", Inorganic Chemistry Exchange (ICE) Workshop, St. John's , Newfoundland , 21-22 Aug., 2014. Jeen, T; Pinter, T.B.J., Stillman, M.J. "Metallation of beta-a Metallothionein", 31st Chemistry Graduate Student Symposium, Buffalo , New York . May 19-21, 2014.

     

    prof. Chris Levy

    • Faculty member on sabbatical from Kansas State University
    •  

    Brit Lewis

    • 4th Year Reasearch Student (2013-2014), thesis title "Metal binding mechanism of metallothioneins"
    • Assisted with the local organizing committee of CanBIC-4 in Parry Sound in 2013
    • B.Sc. (hons)The University of Western Ontario(2014)
    • Conference publications:

    Levy, C;. Lewis, B; Stillman, MJ. "Combining magnetic circular dichroism spectra with TD-DFT results to understand the effects of effects of peripheral substituents on the electronic structure of Zn-porphyrins" (abs121616) International Conference on Porphyrins and Phthalocyanines (ICPP-8), Istanbul , Turkey , June 22-27, 2014.

    Lewis, B., Jarisz, T., Stillman, M.J. “Effects of peripheral substituents on the electronic structure of Zn-anthraquinonoporphyrins” 46th Inorganic Discussion Weekend, November 8-10th, 2013, York University, Toronto, Ontario.

    Jarisz, TA; Lewis, B; Stillman, MJ "Effects of peripheral substituents on the electronic structure of Zn-anthraquinonoporphyrins" 4th Georgian Bay International Conference on Bioinorganic Chemistry, Parry Sound, Ontario, 21st - 25th May, 2013.

     

    Jasjit Singh

    • 2nd YearInorganic Exchange Stduent; Reasearch Student (2013-2014), thesis title "Where does the first metal bind?"
    • Supported by an USRA Scholarship
    • Assisted with the local organizing committee of CanBIC-4 in Parry Sound in 2013
    • B.Sc. (hons) Ryerson University , Toronto (2014) - Currently studying medicine at the U. of T.
    • Conference publications:

    Maria Salgado

    • B.Sc., Ph. D. (2005) The University of Western Ontario
    • PDF and Research Scientist National Institute for Aging (2006-2013)
    • Research Associate at UWO (2013)
    • Currently working at AB Sciex (see LinkedIN entry..)
    • papers with the group include:

    Duncan Ewan Keith Sutherland

    • B.Sc., Ph. D. (2012) The University of Western Ontario
    • Currently attending UWO Medical School
    • Sutherland, D.E.K.; Stillman, M.J. "Challenging Conventional Wisdom: Single Domain Metallothioneins", Metallomics (2014) DOI: 10.1039/C3MT00216K

    Michael Tiedemann

    • B.Sc., Ph. D. (2012) The University of Western Ontario
    • Currently attending UWO Dental School
    • Tiedemann, M.; Heinrichs, D.E.; Stillman, M.J. (2012) "The multi-protein heme shuttle pathway in Staphylococcus aureus: Isd cog-wheel kinetics", J. Am. Chem. Soc. 134, 16578-16585. DOI: 10.1021/ja305115y.

     

    ·                    

    Meredith Gullons

    Gordon W. Irvine , Kelly E. R. Duncan, Meredith Gullons and Martin J. Stillman (2015) "Metalation kinetics of the human α-metallothionein 1a fragment is dependent on the fluxional structure of the apo-protein", Chemistry - A European Journal, 21, 1269-1279. http://dx.doi.org/10.1002/chem.201404283.

  •  

    Alex Easton

    ·                     Undergraduate Student (490 Project)

     

    Thanh Ngu

    o                                            B.Sc., Ph. D. The University of Western Ontario

    o                                            Currently working at AB Sciex (see LinkedIN entry..)

    o                                            papers with the group include:

    Ngu, T. T. Stillman, M. J. (2006) Arsenic binding to Human Metallothionein. J. Am. Chem. Soc. 128: 12473-12483.

    Ngu, T. T., Sturzenbaum, S., Stillman, M. J. (2006) "Cadmium Binding Studies to the Earthworm Lumbricus rubellus Metallothionein by Electrospray Mass Spectrometry and Circular Dichroism

    Ngu, T., Lee, J., Rushton, M.K., Stillman, M.J. (2009) “Arsenic-Metalation of Seaweed Fucus vesiculosus Metallothionein:  The Importance of the Interdomain Linker in Metallothionein”, Biochemistry, 48, 8806-8816.

    T. Ngu; J.A. Lee; T.B.J. Pinter; M.J. Stillman (2010) “Arsenic-Metalation of Triple Domain Human Metallothioneins: Support for the Evolutionary Advantage and Interdomain Metalation of Multiple-Metal-Binding Domains“, J. Inorg. Biochem., 104, 232-244.

    Ngu, T.; Dryden, M.D.M.; Stillman, M.J. (2010) “Arsenic transfer between metallothionein proteins at physiological pH” Biochem. Biophys. Res. Commun. 401, 69-74.

    Ngu, T.; Krecisz, S.; Stillman, M.J. (2010) “Bismuth Binding Studies to the Human Metallothionein using Electrospray Mass Spectrometry”, Biochem. Biophys. Res. Commun. 396, 206-212.

    Ngu, T.T.; Stillman, M.J. (2009) “Arsenic metalation pathways in metallothioneins”, J. Biol. Inorg. Chem., 14, S75.

    Ngu, T; Easton, A; Stillman, M.J. (2008) "Kinetic analysis of arsenic-metalation of human metallothionein: Significance of the two-domain structure." J. Am. Chem. Soc., 130, 17016-17028.

    Ngu, T; Stillman, M.J. (2009) "Metalation of metallothioneins" Dalton Transactions, 5425-5433.  (Featured on the cover).

    Ngu, T; Stillman, M.J. (2009) "Metalation of metallothioneins". IUBMB Life, 61, 438-446 (Featured on the cover).

    Amanda Senior

    • B.Sc.
    • M.Sc. The University of Western Ontario (2007)
    • Currently teaching in Bermuda

    A. Senior, J. Mack, N. Kobayashi and M. J. Stillman (2006) “Π cation radical porphyrinoids: progress towards the assignment of the optical spectrum”, J. Porphyrins Phthalocyanines, 10, 876.

  • Kelly Duncan

    • B.Sc.
    • Ph.D. The University of Western Ontario (2007)
    • Currently senior scientist in Philidelphia

  • Irvine, Kelly E. R. Duncan, Meredith Gullons and Martin J. Stillman (2015) "Metalation kinetics of the human α-metallothionein 1a fragment is dependent on the fluxional structure of the apo-protein", Chemistry - A European Journal, 21, 1269-1279. http://dx.doi.org/10.1002/chem.201404283.

    Rigby, K. E., Chan, J., Mackie, J. Stillman, M. J. (2006) “Molecular dynamics study on the folding and metallation of the individual domains of metallothionein”, Proteins: Structure, Functions and Bioinformatics, 62, 159-172.

    Rigby, K.E. and Stillman, M.J. (2004) “Structural studies of metal-free metallothionein”, Biochem. Biophys. Res. Commun., 325, 1271-1278.

    Duncan, K. E. R., Ngu, T., Chan, J., Salgado, M.T., Merrifield, M. E., Stillman, M. J. (2006) “Peptide Folding, Metal-Binding Mechanisms, and Binding Site Structures in Metallothioneins” J. Exp. Biol. & Med., 231, 1488-1499.

    Duncan, K. E. R., Stillman, M. J. (2006) Metal-dependent protein folding: Metallation of metallothionein, J. Inorg. Biochem. 100, 2101-2107.

    Duncan, K.E.R., Kirby, C., Stillman, M.J. (2008) “Metal-exchange in metallothioneins.  A novel structurally-significant Cd5 species in the alpha domain of human metallothionein 1a”.  FEBS Journal 275, 2227–2239.  

    Duncan, K.E.R., Stillman, M.J. (2007) “Evidence for non-cooperative metal binding to the alpha domain of human metallothionein.”  FEBS Journal, 274, 2253-2261.

    Graduate Students in year order (complete links to come, eventually)

    Tyler Pinter (2015) "Reactions Between Zinc Metallothionein and Carbonic Anhydrase" PhD
    Duncan Sutherland  (2012) "Structural motifs of metallothionein". PhD
    Michael Tiedemann  (2012) "Heme binding and transfer in the Isd heme scavenging pathway of Staphylococcus Aureus". PhD
    Thanh Ngu  (2009) “Arsenic binding to metallothioneins”. PhD
    Amanda Senior  (2007) “Electronic structures of low symmetry porphyrins”. MSc
    Kelly Rigby  (2007) “Kinetic studies of metal-induced protein folding”. PhD
    Mark Pluym  (2007) “Study of heme binding in S. aureus”. MSc
    Salgado, M.T.  (2006) “Copper binding studies of metallothioneins”. PhD
    Chan, J.  (2006) “A metallothionein biofunctionalized gold surface”.  PhD
    Merrifield, M.E.  (2005) “Studies of human and F. vesiculosus metallothioneins”.  PhD
    Du, H.  (1996), “Diagnostic Expert Systems in Instrumental Analysis”. Ph.D.
    Zhu, Q.  (1996), “Expert System Development in Analytical Chemistry”.  Ph.D.
    Green, A.R.  (1995), “Spectroscopic Properties of Copper Binding to Metallothionein”. Ph.D.
    Presta, P.A.  (1995), “Spectroscopic Studies of Copper Binding to Metallothionein”.  Ph.D.
    Li, X.  (1994), “A Spectroscopic Study of Metallophthalocyanines”.  M.Sc.
    Mack, J.  (1994), “Magnetic Circular Dichroism Spectroscopy of Phthalocyanine Anions”.  Ph.D.
    Lahiri, S.  (1994), “Design and Implementation of Expert Systems in Trace Metal Analysis”.  Ph.D.
    Ough, E.  (1992), “Spectroscopic Studies of Metallophthalocyanines”. Ph.D.
    Lu, W.  (1990), “Spectroscopic Studies of Mercury Binding to Metallothionein”.  Ph.D.
    Nyokong, T.  (1986), “Spectroscopic and Electrochemical Studies of Metallophthalocyanines”. Ph.D.
    Law, A.Y.C.  (1984), “Spectroscopic Studies of Metal Binding to Metallothionein”. Ph.D.
    Browett, W.R.  (1981), “MCD of Catalase and Porphyrin Model Compounds”.  PhD.
    Martin, K.A.  (l979), “A Spectroscopic Study of Non transition Metal Phthalocyanines”. M.Sc.

    Visiting Graduate Students

    Lina Heinlein (Sept. 2016 - April, 2017) Copper binding to Zn-MT (from Andrea Hartwig's group at the Karlsruhe Institue of Technology) Judith Scheller (Feb - Dec, 2016) Copper binding to apo-MT (from Andrea Hartwig's group at the Karlsruhe Institue of Technology) Akiko Takashina (July, 2012) Spectroscopic study of cytochrome c' (visiting PhD graduate student; Ibaraki University; Mito, Japan)
    Thandekile Mthethwa (Jan-August, 2012) "Linking phthalocyanines with sulphur-rich proteins" Canadian Commonwealth Scholar – PhD Graduate student from Rhodes University, South Africa.
    Takahide Yamaguchi (June, 2011) Effects of pH and temperature on the copper binding site in Pseudoazurin (visiting PhD graduate student; Ibaraki University; Mito, Japan). Member of prof. Taka Kohzuma’s laboratory; collaborator with MJS.
    Tomonori Muroya (June, 2011) Alkaline transitions of Japanese laccase (visiting PhD graduate student; Ibaraki University; Mito, Japan). Member of prof. Taka Kohzuma’s laboratory; collaborator with MJS.
    Akiko Takashina (June, 2011) Spectroscopic study of cytochrome c' (visiting PhD graduate student; Ibaraki University; Mito, Japan).  Member of prof. Taka Kohzuma’s laboratory; collaborator with MJS.
    Nkosiphile Masilela (February - August, 2010) Canadian Commonwealth Scholar; "Biotechnology of sulphur-rich proteins". (PhD Graduate student from Rhodes University, South Africa)

    Previous Undergraduates (in alphabetical order by first name - publication details in some cases; complete links to come, eventually)

    Alexander Easton  (2007-8)  Time- and Temperature-resolved ESI-MS studies of As(III) binding to metallothionein.
    Andrew Akaleitis  (2001-2)  Metal binding to glutathione using ESI-MS techniques
    Angel Zhang (2015-2016) The electronic basis for strong red absorption: how to mimic chlorophyll
    Anjan Mahrok (May – Aug. 2011) "Counting cysteines – metal-induced protein folding" (ICE scholar; USRA; U/G U of Calgary) [posters & publication - 2012]
    Brad Reed (May-Aug. 2013) Role of metallothioneins in zinc homeostasis. (Dept. of Biology).
    Brandy Moran  (May – Aug 2005) USRA “Development of techniques for making recombinant metalloproteins”
    Brent Windsor  (2008-9)  Experimental support for theoretical predictions of MCD spectra.
    Brittany Lewis (2013-2014) Metal thiolate cluster stabilities in metallothioneins
    Brittany Lewis (April- Aug. 2013) Cadmium binding to metallothioneins [poster-CanBIC-4-2013].
    Carly Hewson  (May – Aug 2009) USRA “Metal selectivity of Isd proteins”
    Christie Magee  (2006-7)  Theoretical analysis of the spectral properties of very large ring compounds.
    Colin Kowalchuk  (1998-99)  Modelling Metallothionein
    Colleen Trevithick  (1998-99)  Kinetics-Metallothionein
    Daisy Wong (2013-2014) Metallothionein and metallodrug interactions
    Daisy Wong (May – Aug, 2014) Metallodrug interactions with metallothionein. The Western Science Undergraduate Pre-thesis Award Graduate at UWO.  [Talk at Graduate Student Research Conference; U. Buffalo, May, 2014; Poster at the CSC National Conference, Vancouver, 2014 June 3; Talk at the Inorganic Discussion Weekend, Montreal, 2014 Nov 14-16] Currently: Graduate Student (OGS-funded) at UWO. 
    Daisy Wong (May, 2011 – April, 2012) "Drug interactions with MT" (U/G UWO.).  Currently: Graduate MSc at UWO.
    Darcy Burns  (1997-98)  Spectroscopy of Metallothionein
    David Ward  (1998-99)  Peptide Synthesis
    Derek Hunter  (Sept. 1998-April 1999) MT-Data analysis
    Donald Thomas  (1998-99)  Metallothionein - Recombinant Prep
    Duncan Sutherland  (2006-7)  Metal binding structures in a novel algal metallothionein from NMR measurements.
    Duncan Sutherland  (May – Aug, 2007) USRA “Structures in metallothioneins by NMR spectroscopy”.
    Elizabeth Kost  (Sept. 1998-April 2000) MT-Isolation
    Fowzia Musa  (Sep 2001- April 2002) Preparation of recombinant Metallothioneins
    Helen Cai  (Sept. 2002 - April, 2003) Research assistant “Computational aspects of protein research”
    Janice Lee  (November 2008 – Aug, 2009) Research assistant. “Kinetics of arsenic binding to metallothioneins”
    Jasjit Singh (May-Aug. 2013) Understanding metallation of metallothioneins by proteolysis and ESI-MS (USRA funded; ICE scholar; U/G Ryerson University).  [poster-Inorganic Discussion Weekend, Nov, 2014, York U; Talk: ICE Workshop, Aug., 2014, U   Calgary].Currently: 4th yr. U/G at Ryerson University.
    Jayna Chan  (1999-2000)  Surface studies of protein-modified gold
    Jess Uzonyi (2014-2015) Detoxification of ginseng extracts, Biology 4999E - supervisor prof E. Lui (Pharmacology & Toxicology; MJS Advisory Committee member from dept. of Biology).
    Jordan Rostowsky (2015-2016) Copper binding to metallothioneins
    Joseph Le Faive (2014-2015) Solution structures of metallothionein
    Josephine Lo (2005-6)  Mechanism of copper binding to mammalian metallothionein.
    Justin Norris  (1999-2000)  Development of techniques for recombinant protein production
    Karen Au (2005-6)  Mercury binding to mammalian proteins.
    Kelly Rigby  (2001-2)  Metal binding kinetics of metallothionein
    Kristen King  (2009-10)  Binding As(III) to wheat metallothionein where domains are separated by long linkers.
    Kyle Jeffs  (2011-2012)  Understanding the colour in nonsymmetric porphyrins
    Laurel Ryan  (May – Aug 2005) USRA “Theoretical analysis of porphyrin spectral data”
    Lauren Vysohlid (May - Aug. 2014) Topological effects to cysteines when As(III) binds to metallothioneins. .  Currently: 4th U/G UWO.
    Linda Forrester  (1996-97)  Kinetics of Metallothionein
    Lindsay Jackson  (Sept 2009 – July, 2010) research assistant. “Metal binding to proteins”.
    Lisa Cameron  (1996-97)  NMR of Metallothionein
    Lydia Kwan  (2010-2011)  Electronic structures of novel porphyrins
    Maria Salgado  (1999-2000)  Metal binding kinetics of metallothionein
    Mark Pluym  (2004-5)  Iron binding in Isd proteins of S. aureus.
    Mark Pluym  (May – Aug 2005) USRA “Studies of bacterial heme proteins”
    Matt Colbear (May - Aug. 2014) Metal binding studies in metallothioneins  Currently: 5th yr BSc/MSc at U East Anglia, UK.
    Maureen Merrifield  (1999-2000)  Mass spectrometry of proteins
    Maysaa Assaf (2012-2013) Binding manganese to metallothioneins
    Meiyen Lee  (May - July 2003) Research assistant “Preparation of recombinant protein”
    Melissa Santolini (2015-2016) Solution structures of metallothioneins
    Meredith Gullens  (2007-8)  Mechanism of Cd(II) binding to metallothionein through stopped-flow studies.
    Michael Dryden (May - Aug, 2010) ICE scholar; USRA; "AsMT as an As(III) ligand" (U/G U of Saskatchewan) [publications: 2010 & 2012]. .  Currently: PhD Graduate at U of Toronto.
    Mikayla Johnson (2015-2016) Metallation properties of 33 cysteiens in a chain.
    Minh Pham  (Sep 2001- April 2002) Computational aspects of protein research
    Moira Rushton (2006-7)  Mechanism of arsenic binding to an algal metallothionein.
    Sandra Krecisz  (2009-10)  Finding metals that react slowly with metallothioneins.
    Scott Hendriks (2014-2015) Comparison of cluster stabilities from the electronic structures
    Sean Simpson  (1998-99)  Merrifield Synthesis of MT
    Stephanie Dingwall  Sept. 1997-April 1998)  Studies of Metallothionein
    Stephen Keizer  (1998-99)  Spectroscopy-Phthalocyanines
    Tasha Jarisz (May - Aug., 2012) "Understanding long wavelength absorption in porphyrins using absorption, MCD and theoretical techniques" ICE scholar; USRA funded; U/G U of Victoria, BC. [poster-CanBIC-4 2013].
    Thanh Ngu  (May - Aug, 2004) USRA “Arsenic binding to proteins using ESI-MS techniques”
    Thanh Ngu (2003-4)  Arsenic binding to proteins using ESI-MS techniques.
    Tiffany Jeen (May - Aug. 2014) Metal competition studies in metallothioneins.  ICE Scholar.  Currently: 3rd year U/G at U. Saskatchewan; USRA funded [poster-U. Buffalo, Graduate Student Research Conference; May, 2014; Talk at the ICE Workshop in St John’s, NF, Aug 2014; Poster at Summer Research Presentations, Dept of Chemistry, U. Saskatchewan (2nd prize & audience prize)]
    Tyler Pinter  (2009-10)  Determining the factors that allow protein-protein interactions that facilitate heme transfer.
    Tyler Pinter  (May - August, 2008; Sept. 2008 – August 2009); USRA (08) & research assistant (09): “Metallation properties of concatenated metallothionein domains”
    Tyler Pinter (May – Aug, 2010)  "Heme-analogues for Isd transport" (U/G, UWO) [posters & publications]
    Xiangyang Huang  (Sept 2001- April 2002) Computational aspects of protein research
    Yifan Lu  (2009-10)  The sensitivity of Isd heme transfer to ring type.


    Also from this web page:

    Group News

    Welcome back Angel Zhang to continue her explorations of the wonders of chlorophyll's electronic structure.

    Welcome 2016-2017 Chem 4991 Student: Deborah Chan

    We are pleased to welcome Ms. Lina Heinlein from the Karlsruhe Institute of Technology (KIT) who will work on copper binding to MT.

    During the summer (May-August, 2015) we welcomed Evan Walters from the Memorial University of Newfoundland as an ICE Scholar - he will be continued Angel Zhang's work only on the compounds provide by our Czech friends: Petr Zimcík.

    We welcome Devika Jayawardena as a new MSc (biology) grad student.

    We are pleased to welcome Ms Judith Scheller from the Karlsruhe Institute of Technology (KIT).

    Welcome 2015-2016 Chem 4991 Students:

    Mikayla Johnson, who is working on metallation of triple alpha (Josephine's old project); Jordan Rostowsky, who ius working on copper binding - following up our zinc work; Melissa Santolini, who has sorted out cysteine modifications and next moves to ms-ms following Jasjit's work; and Angel Zhang, who is working on exploring the electronic basis for strong red absorption: how to mimic chlorophyll.

    Welcome Summer Students:

    We welcome ICE and USRA-funded students to work with us in the summer and learn the intricacies of metal-based biological chemistry