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Stillman Research Group (2008)

Research Interests

Arsenic Binding to Metalloproteins

Metal Binding Motifs in Metallothioneins

Electronic structures in Phthalocyanines and Porphyrins

Effects of Ring Oxidation and Reduction on the Spectral of Phthalocyanines and Porphyrins

Metal-induced Protein Folding

Iron Acquisition in Staphyloccocus aureus (the Isd Pathway)

Theoretical Aspects of Porphyrinoid Spectroscopy

Our techniques and methods

Metalloprotein metallation studies

Over-expression of metalloproteins

Extensive use of time- and temperature-dependent electrospray mass spectrometry

Use of absorption, emission, CD, magnetic CD, NMR, and X-ray spectroscopy, together with stopped-flow-methods

Modelling studies of protein metallation and folding

Our theoretical studies of porphyrinoids uses DFT methods

Electrochemical studies of porphyrinoids for cation and anion radicals

Theoretical Aspects of Porphyrinoid Spectroscopy uses DFT methods

Theoretical Aspects of Porphyrinoid S pectroscopy uses DFT methods

Links of Interest

University of Western Ontario

UWO Chemistry Department

Studying at Western

City of London

News

July, 2010

ICPP-6 in New Mexico

Martin and Mike Tiedemann participate in ICPP-6. Martin is co-organizer of symposia on "Theoretical Methods in Porphyrinoids" (25) and "Spectroscopy in Heme Proteins" (18) and gives an invited talk about Isd proteins. Mike presents a poster on Isd proteins.

June, 2010

Canadian Society of Chemistry National Conference in Toronto

Martin gives a lecture on Metallothioneins in the Bioinorganic Symposium organised by Deborah Zamble (U of T).

May, 2010

April, 2010

Martin will visit China for a tour of research labs

Martin will talk on Porphyrins and Metallothioneins in Beijing, Nanjing, Shanghai and Hong Kong

Talk to IBMB at Waterloo

Martin's talk is on the kinetics of As(III) binding to metallothioneins; 3:30 pm on April, 6th.

March, 2010

4th year conference at UWO and 4490-Day

Each of the 4th year students (Sandra, Kristen, Arthur, Tyler) presented talks on their research successes at the annual 4th year research conference held at Western on Saturday, 20th March.

February, 2010

Duncan Sutherland attends Metals in Biology Gordon Conference

Duncan travels to California to attend the Bioinorganic Chemistry Gordon Research Seminar

Martin visits Grenoble & Lausanne

Martin took part in a site visit of the Metals in Biology Research Centre in Grenoble. He also visited EPFL at Lausanne to discuss recent results from Lindsay with Angela Casini and Paul Dyson; finally visits Steve Sturzenbaum at King's College before flying home for the UWO reading Week.

January, 2010

Ibaraki Univ for UV Res Raman and then to Tohoku Univ

Martin travels to Mito in Japan to visit Prof Taka Kohzuma to try out a new experiment on the Cd-clusters in MT with his group. After this Martin travels with Nagao Kobayashi to Ueda and then to Sendai to work in Nagao's lab for 2 weeks.

December, 2009.

End of term and Christmas break

November, 2009.

Visit to Europe

Martin travels to labs in Eindhoven (Merkx), Zurich (Freisinger), Lausanne (Casini & Dyson), King's (Sturzenbaum) and Warwick (Blindauer & Sadler) to give talks and discuss collaborative projects. Martin and Claudia Blindauer run a week-long workshop on Bioinorganic Methods and Ideas in Warwick - "Metals in Life's Processes".

October, 2009.

Nothing happened in October!

September, 2009.

A New Year: New faces - New projects

Tyler Pinter, Arthur Yu, Kristen King and Sandra Krecisz join for their 4th year research projects.

Lindsay Jackson (in 4th year Biology) has joined the group as a research assistant to work on metal binding to metallothioneins. See 2010 for report of her successes with compounds from EPFL.

July, 2009.

ICBIC 14 in Nagoya, Japan

The group travels to Japan.

Martin Stillman, Mike Tiedemann and Duncan Sutherland all travel to Japan to attend ICBIC-14 in Nagoya. Martin gives lectures at the Ibaraki University in MTO (Isd studies), and Tohoku University in Sendai (Isd studies), then at ICBC-14 (As-MT ESI-MS studies) and finally at the post-ICBIC Mito Bioinorganic Symposium (As-MT ESI-MS studies).
Duncan and Mike present posters at ICBIC-14.

June, 2009.

Thanh officially graduates with her Ph.D.

May, 2009.

The Stillman group members organize the 2nd Georgian Bay International Conference on Bioinorganic Chemistry in Parry Sound

Martin is the Conference Chair, with Nagao Kobayashi and Frank Shaw as the organizing committee
John, Duncan, Mike, Janice, Tyler, Carly, Susan H?, David Stillman are the local organizing committee

Our group makes several presentations and posters
Tiedemann, M.T., Muryoi, N., Heinrichs, D.E., Stillman, M.J. “Heme Transfer Pathway in Staphylococcus aureus using Electrospray Ionization Mass Spectrometry and Magnetic Circular Dichroism spectroscopy.”
Hewson, C. J.; Tiedemann, M. T.; Stillman, M. J. “Spectroscopic Properties of Myoglobin as a Function of Axial Ligand.” 
Lee, J.A.; Ngu, T.T.; Rushton, M.K.; Stillman, M.J. “The Arsenic Metallation Pathway in Seaweed Fucus Vesiculosus Metallothionein.” 
Pinter, T.B.J.; Lee, J.A.; Ngu, T.T.; Stillman, M.J. “Domain Dependence of the Arsenic Metalation of Metallothionein.”
Sutherland, D.E.K., Stillman, M.J. “Metallation properties of alpha and beta human metallothioneins.” May, 2009.

Carly Hewson and Tyler Pinter join the group as summer students

April, 2009.

Duncan and Mike receive travel scholarships to attend ICBIC-14 in Nagoya

February, 2009.

Martin goes to South Africa to give two talks

To the Joint JSPS/NRF South Africa Workshop: “Spectroscopic and theoretical studies towards answering the question: Why isn’t grass red and blood green?” 

To the Department of Chemistry, University of Cape Town: “Mechanism of Arsenic(III) binding to Metallothioneins: Time- and temperature-dependent kinetic studies using electrospray mass spectrometry”.

November, 2009.

Lee joins the group as a research assistant

The group participates in the Inorganic Discussion Weekend at Brock University

September, 2009.

Martin is a Topic Lecturer at the European Chemical Congress in Turin       

Martin gives an invited talk: “Metal binding mechanisms in metallothioneins”. September, 2008.

Duncan is awarded a travel scholarship to attend the Tohoku University Summer School.
Duncan gives a talk entitled “Metal thiolate cluster motifs in the protein metallothionein”, to the Tohoku University Global Center of Excellence (COE) Summer School, Sendai, Japan.

July, 2008.

Martin and Mike travel to Moscow for ICPP-5
Martin gives an invited lecture "Theoretical and spectroscopic advances in the interpretation of the electronic spectra of porphyrins and phthalocyanines"
John Mack, coauthored with Martin and Nagao Kobayashi, gives an invited talk: "MCD spectroscopy and the effect of porphyrinoid ligand non-planarity: core modified tetrabenzoporphyrins”
Mike presents a poster.

January, 2008.

Michael Tiedemann wins scholarshipstrong>

Michael Tiedemann has been awarded a Graduate Thesis Research Award which helps to provide travel funds to attend and present his work at ICPP-5 in Moscow in July, 2008.

Thanh Ngu Heads to London, England for 3 weeks research with Stephen Sturzenbaum's group!

Thanh Ngu is spending 3 weeks in King's College, London, with Stephen Sturzenbaum working on metallothionein (she comes back after a week in Paris!)  Thanh's travel was supported by an ASPIRE Award.

June, 2008.

Biochemical Society Focused Meeting, Norwich, UKstrong>

Martin Stillman was invited to speak at the Biochemical Society Focused Meeting entitled Transition Metals in Biochemistry in June, 2008.

Martin speaks at his old University on the occasion of Andrew Thomson's retirement
“Understanding iron acquisition in Staphylococcus aureus using MCD spectroscopy and mass spectrometry”.

Martin travels to Alberta to speak at the University of Calgary and 92nd Canadian Chemical Conference
“Understanding geometrical control of the colours of porphyrins – understanding novel magnetic circular dichroism spectroscopic spectra of a saddled porphyrin.  Or, why isn’t our blood green and grass red?”
 “Understanding iron acquisition in Staphylococcus aureus using MCD spectroscopy and mass spectrometry”  in the  “Symposium on Bioinorganic Chemistry” 
“The Mechanism of Arsenic Binding to Metallothioneins from Time and Temperature-Resolved ESI-MS”  in the  “Symposium on Bioinorganic Chemistry”

Stillmangroup at IDW 2007!

The Stillman Group went to The University of Toronto for the Inorganic Discussion Weekend conference (IDW). Photos can be found here!

Welcome New Group Members!

We welcome two new graduate students: Michael Tiedemann and Duncan Sutherland. We also welcome our two undergraduate thesis (490 Project) students: Meredith Gullons and Alex Easton! For more information please see the people section.

1st Georgian Bay International Conference

The 1st Georgian Bay International Conference on Bioinorganic Chemistry will be held in and around the Parry Sound area in May 2007. For more information please see the conference website.

A few photos

2009 and 2010

to come photos from visits and conferences. Find our full set on Shutterfly - link to come soon

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Joining our group for graduate studies or for your 4th year project

If you are interested in joining the Stillman Bioinorganic Group for graduate school have a look here for more information about submitting an application. Research in our group offers a wide range of stimulating experiences at the boundary between inorganic chemistry and biology. Metals control life! Join us to find out how by studying one of our systems.

 

 

 

Events

3rd Georgian Bay Conference on Bioinorganic Chemistry

CanBIC (May 31st - June 3rd, 2011 in Parry Sound.)

ICPP 6

Conference July 4-9, 2010 in New Mexico, USA

CSC Conference

31st May - 2nd June 2010 in Toronto

2nd Georgian Bay Conference on Bioinorganic Chemistry

CanBIC (May 26-29 2009)

IDW 2008

Conference Nov 28-30 2008

ICPP 5

Conference July 7-11 2008

IDW 2007

Conference Nov 2-4 2007

1st Georgian Bay Conference on Bioinorganic Chemistry

CanBIC (May 22-25 2007)


 

Research Links